半胱氨酸天冬氨酸特异性蛋白酶介导的细胞凋亡对精子发生发育及冷冻保存的影响

Influences on Apoptosis Mediated by Caspases on Spermatogenesis, Development and Cryopreservation

半胱氨酸天冬氨酸特异性蛋白酶(cysteinyl aspartate specific proteinase,Caspase)是直接导致凋亡细胞解体的蛋白酶家族,在细胞凋亡机制网络中处于中心地位。在精子发生发育过程中,机体通过生殖细胞凋亡与细胞增殖平衡机制来确保正常数量和质量的精子分化与成熟。精子冷冻保存会对精子造成不可逆的冷冻损伤,冷冻-解冻后,一些标志性凋亡现象会显著增多。作者对Caspase介导的细胞凋亡对精子发生发育及冷冻保存的影响机制进行了综述,表明精子发生发育和冷冻损伤与精子细胞凋亡存在密切的联系。

Caspase is a family of cysteine proteases that play an important role in regulating apoptosis. Spermatogenesis and development involve an early waves of germ cell apoptosis, which are required for maintaining the balance between germ cell proliferation and death, to ensure sufficient number and quality of well differentiation and mature spermatozoa. Main reasons probably owe to structural damage, functional lost of boar spermatozoa and apoptosis during cryopreservation, which finally lead to sperm program cell death, apoptosis. The present paper reviewed the influence mechanism of apoptosis mediated by caspase, which showed tightly relationship between apoptosis mediated by caspase and spermatozoa cryopreservation, spermatogenesis and development.