摘要
胃癌和大肠癌是世界范围内常见的胃肠道肿瘤.鉴于胃癌和大肠癌的发生发展、转移及复发为多因素、多步骤的错综复杂的过程,受多种相关因子的调控,因此对这一过程中相关调控因素及其对预后的判断及指导治疗的研究等引起了学术界的广泛关注.近年研究表明胸苷酸合成酶(thymidylate synthase,TS)与上述过程关系密切,主要涉及胃癌和大肠癌的发生发展、化疗效果及预后等诸多方面,其中一些在学术界已达成共识,但仍有许多问题存在较大的争议.本文就TS基因多态性及其与胃癌和大肠癌的关系作一综述.
Gastric cancer and colorectal cancer are the most common gastrointestinal tumors worldwide. The development, metastasis and recurrence of gastric cancer and colorectal cancer are complex and are affected and regulated by many factors. These factors have important significance in guiding treatment and predicting prognosis. Recent studies have shown that thymidylic acid synthase （TS） is closely related with the occurrence, chemotherapy and prognosis of gastric cancer and colorectal cancer; however, there is still some controversy over this view. This review discusses the relationship between TS gene polymorphisms and gastric cancer and colorectal cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第10期865-872,共8页
World Chinese Journal of Digestology
基金
福建省大学生创新创业训练计划基金资助项目
No.C12023~~
关键词
胸苷酸合成酶
基因多态性
耐药
胃癌
大肠癌
Thymidylate synthase
Gene polymorphism
Drug resistance
Gastric cancer
Colorectal cancer
