异丙托溴铵雾化气道治疗慢性阻塞性肺疾病急性加重期的疗效观察

The efficacy of airway nebulization with ipratropium bromide for acute exacerbation of chronic obstructive pulmonary disease

目的观察比较异丙托溴铵经气道超声雾化和氧气雾化吸人治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法对本院呼吸内科收治的306例慢阻肺急性加重期患者进行异丙托溴铵雾化治疗，观察两组患者的雾化治疗前后的指脉氧、症状及体征变化，对数据进行统计学分析。结果氧气雾化组疗效（总有效率94．16％）明显优于超声雾化组（总有效率68．42％），P〈O．05。结论异丙托溴铵经气道氧气雾化治疗慢阻肺急性加重期具有良好的临床疗效。

Objective To compare the clinical efficacy of airway ultrasonic nebulization with ipratropium bromide with that of oxygen mist inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods 306 patients with acute exacerbation of chronic obstructive pulmonary disease received airway nebulization with ipratropium bromide. Finger pulse oxygen and symptoms and signs were observed, and the related data were analyzed statistically. Results Airway ultrasonic nebulization is superior to oxygen mist inhalation in the efficacy （94.16% vs. 68.42% in total effectiveness rate, P〈0.05） Conclusions Airway ultrasonic nebulization with ipratropium bromide has better clinical efficacy in the treatment of acute exacerbation of chronic obstructive pulmonary disease.