美金刚联合通心络治疗遗忘型轻度认知障碍的研究

Study on memantine combined with tongxinluo in treatment for atones-tic mild cognitive impairment

目的探讨美金刚联合通心络治疗遗忘型轻度认知障碍（aMCI）的临床疗效。方法分析我院2010年12月至2012年8月收治的70例遗忘型轻度认知障碍患者的临床资料，采用随机数字表法分为治疗组（美金刚联合通心络）和对照组（单用美金刚），各35例，对比半年后两组治疗疗效。结果在治疗后，治疗组简易精神状态量表（MMSE）评分和延迟故事回忆（DSR）显著高于对照组（P〈0．05）。两组均未出现由药物引起的各种不良反应（P〉0．05）。结论美金刚联合通心络是一种疗效好、无毒副作用的治疗遗忘型轻度认知障碍的好方法，能够明显改善患者的临床症状，加快患者的康复，在临床上值得推广应用。

Objective To study the clinical curative effect of the method of memantine combined with tongxinluo in treatment for amnes-tic mild cognitive impairment （aMCI）. Methods We retrospectively analyze the clinical data of 70 cases of patients affected with aMCI from December 2010 to August 2012, they were randomly divided into treatment group （memantine combined with Tongxinluo capsule ） and control group （single memantine）, 35 cases for each group, half a year later, we compared the efficacy of the treatment in the two groups. Results After treatment, the score of mini mental state exam （MMSE） and delayed stol＂y recall （DSR） in the treatment group were significantly higher than those in the control group （P〈0.05）. Adverse reaction, which was caused by drug intake, did not appear in the patients of both groups. Conclusion The method of memantine combined with tongxinluo, only has good curative effect, but without non-toxic side effects in the treatment of aMCI, it can obviously improve the clinical symptoms of patients, accelerate their recovery. So it is worth for applying in clinic.