左氧氟沙星与阿奇霉素序贯疗法对社区获得性肺炎的临床治疗

Clinical Study of Levofloxacin and Azithromycin Sequential Therapy in the Treatment of Community Acquired Pneumonia

目的评价左氧氟沙星与阿奇霉素序贯疗法在社区获得性肺炎(CAP)临床治疗中的疗效和用药安全性.方法将224例CAP患者随机分为A组(左氧氟沙星组)和B组(阿奇霉素组),两组患者在给药前均进行必要的标本采集,两组患者按照各自的规定剂量给药,完成治疗后进行回顾性分析,评价两组患者的疗效及安全性.结果 A组较B组患者在痊愈率、有效率和临床理化指标上均有提高,差异具有统计学意义(P<0.05);A组患者的细菌菌株清除率较B组患者有显著提高,差异具有统计学意义(P<0.05);两组患者用药过程中均未出现严重的不良反应,差异无统计学意义(P>0.05).结论左氧氟沙星序贯疗法治疗在CAP的治疗过程中显示了良好的治疗效果和细菌清除率,该疗法安全可靠、经济便捷,可用于临床推广.

Objective To evaluate the effect of levofloxacin and azithromycin sequential therapy on the community acquired pneumonia （CAP） and the safety of it. Method 224 Patients with CAP were randomly divided into group A （levofloxacin group）and group B （azithromycin group）, and some valuable samples from the patients in two groups were collected before the administration. The patients in the two groups were administered according to given administration doses and a retrospective analysis was performed after the completion of treatment for the evaluation of efficacy and safety of the therapy in the two groups. Results The recovery rate, efficiency and clinical physical and chemical indicators of patients in group A were improved compared with those of patients in group B, and the differences were statistically significant（P 〈 0.05 ） ;the strains clearance rates in patients in group A were higher than those in patients in group B significantly, the difference was statistically significant （ P 〈 0.05 ） ; no serious adverse reactions were found in the two groups during the process of treatment, the difference between them was not no significant （ P 〉 0. 05 ）. Conclusion The therapy of levofloxacin sequential therapy in the treatment of CAP showed a good therapeutic effect and bacteria clearance rate, the therapy is safe and reliable, economic and convenient, and it can be widely used in clinic.