有机溶剂在生物酶法制备D-羟基苯甘氨酸中的应用

Enzymatic Synthesis of D-(hydroxyphenyl) Glycine in Presence of Organic Solvent

在生物酶法制备D 对羟基苯甘氨酸反应中加入一定量的二甲亚砜 ,可以克服DL 对羟基苯海因溶解度太低的限速因素 ,从而可以提高反应速度及增加产率。二甲亚砜最佳用量为 10 %。与不加二甲亚砜相比 ,酶转化率增高近 5倍。

During enzymatic synthesis D p hydroxyphenylglycine, DMSO can promote the reactive speed and increase the yield of D p hydroxyphenylglycine because of increasing the solubility of D p hydroxyphenylhydantoin The optimum concentration of DMSO is 10% Comparing with without adding DMSO, the rate of conversion of dihydropyrimidinase almost increases 5 times