非洛地平缓释片治疗肾性高血压的临床疗效及对生活质量的改善作用

Clinical effects of felodipine sustained-release tablets for renal hypertension and its improvement effect on the quality of life

目的探讨钙离子拮抗剂非洛地平缓释片治疗肾性高血压的临床疗效及对生活质量的影响。方法将100例肾性高血压患者随机分为2组,每组50例。对照组给予福辛普利钠片,观察组给予非洛地平缓释片。比较2组患者总体疗效,血压、尿蛋白、血肌酐、生活质量的改善以及不良反应发生率。结果观察组总有效率显著高于对照组;2组患者治疗后血压、尿蛋白及血肌酐水平均较治疗前显著改善,而观察组尿蛋白水平的改善幅度显著大于对照组;观察组生活质量核心问卷-30(QLQC-30)各项评分均显著高于对照组。观察组不良反应发生率有低于对照组的趋势,但差异无统计学意义。结论钙离子拮抗剂非洛地平缓释片治疗肾性高血压疗效显著,可明显提高患者治疗后生活质量,应在临床上加以推广应用。

Objective To investigate the clinical effects of calcium antagonist felodipine sus- tained-release tablets in the treatment of renal hypertension and its improvement effect on the quality of life. Methods One hundred patients with renal hypertension were randomly divided into two groups, 50 cases in each group. The control group was administered fosinopril sodium tablets, while the observation group recieved felodipine sustained-release tablets. The total therapeutic effect, im- provement of blood pressure, urine protein, serum creatinine and quality of life as well as incidence of adverse reactions of patients were compared in both groups. Results The total effectiveness rate in the observation group was obviously higher than that in the control group. The levels of blood pressure, urine protein and serum creatinine after treatment all improved, and the improved degree in the observation group was obviously larger than that in the control group. Each score of the quali- ty of life questionnaire core-30 （QLQC-30） in the observation group was obviously higher than that in the control group. The incidence of adverse reactions in the observation group had a tendency lower than that in the control group, but there was no significant difference. Conclusion The calci- um antagonist felodipine sustained-release tablets in the treatment of renal hypertension has a signifi- cant therapeutic effect, and it can significantly improve the quality of life after treatment, so it should be promoted and applied in clinical practice.