拉坦前列素和噻吗心安治疗开角型青光眼、高眼压症的对照研究

A randomized parallel group study comparing Latanoprost treatment with timolol in patients with open angle glaucoma or ocular hypertension

目的 :观察 L atanoprost的降眼压效果及安全性。方法 :采用随机分组对照法 ,0 .0 0 5 % L atanoprost每日一次或 0 .5 % Timolol(噻吗心安 )每日 2次 ,治疗原发性开角型青光眼、高眼压症和剥脱性青光眼 ,共 14例 ,疗程 12周 ,观察其眼压及不良反应。结果 :L atanoprost组和 Timolol组均可有效地降低眼压 (P<0 .0 1) ,两组间眼压下降值没有差异。两组治疗前后不同时间点眼压下降值没有波动。有 2例用 L atanoprost患者出现结膜充血 ,未发现其他眼部改变和全身副作用。结论 :研究表明 L atanoprost是一种稳定、有效的降眼压药物 ;眼局部反应轻微 ,没有全身副作用。 L atanoprost可望成为一种安全。

Objective:To investigate the effect of Lowering intraocular pressure and side effect of Latanoprost Methods:using randominzed parallel group control study 0 005% latanoprost once a day or 0 5% timolol twice a day was applied in patients with primary open angle glaucoma,ocular hypertension or exfoliative glaucoma for 12 weeks Results:The IOP of patients in latanoprost group and timolol group was decrcased with statistical significance(P<0 01) There was no significant difference between the two groups There was no difference of IOP reduction between two groups at different times before and after treament Two patients with latanoprost had conjunctival congestion No other ocular and systemic adverse events related to the drugs were found Conclusion:The results of this study demonstrated that latanoprost is a stable and effective antiglocoma medicine with well tolerance Thus,latanoprost has the potential for becoming a new first line antiglaucoma medicine