槲皮素醇质体凝胶剂的研制

Preparation of the Topical Gel Based on Quercetin-Loaded Ethosome

制备槲皮素醇质体凝胶剂并进行质量评价及其抗炎作用的研究。采用注入法制备槲皮素醇质体,再加入适量卡波姆制成凝胶剂。对槲皮素醇质体的形态、粒径、表面电位、包封率、载药量进行了考察,并研究了其抗炎作用。结果表明得到的槲皮素醇质体为类球形,粒径分布均匀,平均粒径为352.7 nm,Zeta电位为-10.78 mV,包封率为61.25%,载药量为3.05%,具有明显的抗炎作用。以上结果说明所制备的槲皮素醇质体凝胶剂性质稳定,具有良好的应用前景。

To prepare the topical gel based on quercetin-loaded ethosome and to evaluate its characteristics and anti-inflammatory activity in rats,the quercetin-loaded ethosomes were prepared by injection method and the gels were prepared with carbomer as the gel base. The formulation of ethosomes was optimized based on encapsulation efficiency and drug loading as index. The morphology, particle size and Zeta potential were detected, and the anti-inflammatory activity of the topical gel based on quercetin-loaded etho- some was studied. The results showed that the obtained ethosomes were spherical under transmission electron microscope, and the mean size and Zeta potential were 352.7 nm and -10.78 mV,respectively. The mean entrapment efficiency was 61.25% and the mean drug loading was 3.05%. The optimal ethosome gel showed stable characteristics and remarkable anti-inflammatory activity and. It will reveal a promising future for applications.