肝康Ⅱ号对慢性乙型肝炎肝硬化患者血清IL-6和IL-8的影响及临床意义

No.Gankang Ⅱon chronic hepatitis B patients with cirrhosis of serum IL-6 and IL-8 impact and clinical significance

目的探讨肝康Ⅱ号对慢性乙型肝炎肝硬化患者血清IL-6和IL-8的影响及临床意义。方法选取临床确诊40例慢性乙型肝炎肝硬化患者,治疗前于清晨空腹采血。肝康Ⅱ号治疗4周后于清晨空腹采血,分别标记为治疗前组和治疗后组;同期选取体检健康的20例健康人作为正常对照组。采用ELISA法检测各组血清IL-6和IL-8的水平。结果与正常对照组比较,治疗前组患者血清IL-6和IL-8的水平明显升高有统计学意义(P<0.01);治疗后组患者血清IL-6和IL-8的水平略升高但无统计学意义(P>0.05);治疗后组患者血清IL-6和IL-8的水平明显低于治疗前者有统计学意义(P<0.01)。结论 IL-6和IL-8水平的变化可作为肝康Ⅱ号临床初始治疗慢性乙型肝炎肝硬化患者疗效的辅助检查指标之一。

Objective To explore No. Gankang Ⅱ on chronic hepatitis B patients with cirrhosis of serum IL-6 and IL-8 impact and clinical significance. Methods Select a clinical diagnosis of 40 patients with chronic hepatitis B patients with cirrhosis,befor-e treatment,fasting blood collection and fasting blood was collected after 4 weeks of treatment of the No. GankangⅡ, Are labeled before treatment and after treatment gro-up; 20 healthy people select a physical exam- ination health at the same as the normal control group. Detected by ELISA in serum level of IL-6 and IL-8. Results Compared with control group,levels of serum IL-6 and IL-8 were significantly higher before trea-tment was statistically significant（P^0.01） ; Groups after treatment serum IL-6 and IL-8 level slightly elevated but not statistically signifi- cant（P〉0. 05）; After treatment,the levels of serum IL-6 and IL-8 were significantly lower than the treatment of the former was statistically signicant（P〈0.01）. Conclusion IL-6 and IL-8 level change as a clinical initial No. Gankang II laboratory examinations indicator of the efficacy the treatment of chronic hepatitis B patients with cirrhosis.