血清鳞癌抗原SCC-Ag测定在诊断宫颈癌复发中的意义

Significance of squamous cell carcinoma antigen in estimation of recurrent cervical squamous carcinoma

目的:评价血清鳞状细胞癌抗原(SCC-Ag)的测定在诊断宫颈癌复发中的作用。方法:回顾分析安徽省立医院2006年6月～2012年3月经影像学或病理证实的86例宫颈鳞癌治疗后达到完全缓解(CR)的患者,采用雅培公司提供的全自动免疫分析系统(Axsym)检测血清SCC-Ag数值,比较分析该抗原改变的临床意义。结果:86例宫颈鳞癌患者中29例发生复发,复发患者SCC-Ag检测值均数明显高于未复发患者;SCC-Ag最佳临界值为1.6μg/L,灵敏度为93.1%,特异度为91.2%。宫颈癌复发诊断中SCC-Ag检测结合正电子发射计算机断层显像/计算机体层扫描(PET-CT)检查早期检出率可能优于其他影像学检查。结论:血清鳞状细胞抗原是宫颈鳞癌较特异的肿瘤标志物,可做为判断宫颈鳞癌复发的辅助诊断指标,其结合PET-CT可能有助于提高复发性宫颈鳞癌的早期诊断率。

Objective： To evaluate the role of squamous cell carcinoma antigen（SCC-Ag） in diagnosis of recurrent cervical squamous carcinoma. Methods：Biomarkers of serum SCC-Ag measured with Axsym were re- viewed in 86 cervical squamous carcinoma patients with complete remis- sion（CR） undergone pathological and imaging confirmation in Anhui Provincal Hospital between June 2006 and March 2012, and the findings were retrospectively analyzed for estimation of the clinical significance to determine SCC-Ag expression. Results ： Relapse of cervical cancer was in 29 of the 86 cases whose mean SCC-Ag were significantly elevated as compared with those of non-recurrence. The best critical value, sensitivity and specificity of SCC-Ag in estimation of the recurrent cervical cancer was 1.6 μg/L,93. 1% and 91.2%, respectively. In addition, PET-CT had a favorable compatibility with the final diagnosis of the recurrence. Conclusion：Serum ACC-Ag is a specific marker for diagnosis of cervical squamous carcinoma,and detection of this biomarker in combination with PET-CT examination may improve the early detection rate in estimation of recurrent cervical cancer.