两种方法制备薄荷油β-环糊精包合物的工艺比较

Comparison of two different methods for preparation inclusion compound of β-cyclodextrin with Peppermint Oil

目的比较饱和水溶液法和超声法制备薄荷油β-环糊精包合物的工艺。方法选用适量薄荷药材,提取薄荷油,分别用饱和水溶液法和超声法制备薄荷油β-环糊精包合物。结果与超声法相比,饱和水溶液法制备薄荷油β-环糊精包合率和包合物的收率均较高;并通过正交试验确定了饱和水溶液法最佳包合工艺为薄荷油(ml)∶β-环糊精(g)为1∶5、搅拌时间为1 h、包合温度45℃,β-环糊精(g)∶水(ml)为1∶10。结论优选的饱和水溶液法包合工艺合理、结果较好,并且操作更为简便。

Objective To compare the methods of saturated water solution and ultrasonic for preparation inclusion compound of β-cyclodextrin with peppermint oil. Methods After extraction of peppermint oil, the inclusion compound of β-cyclodextrin with peppermint oil was prepared by saturated water solution method and ultrasonic method. Results The better inclusion method was sat- urated water solution with higher inclusion rate and yield of inclusion compound. And the optimum inclusion conditions were as follows： peppermint oil（ml） ： β-cyclodextrin（g） = 1： 5, stirring for 1 hour, 45℃ , β-cyclodextrin（g） ： water（ml） = 1： 10. Conclusion The better inclusion method was saturated water solution which was reasonable and convenient.