1Shen ZX, Chen GQ, Ni JH, et aL Use of arsenic trioxide (As203) in the treatment of acute promyelocytic Leuke- mia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients [J] .Blood, 1997,89:3354-3360.
2Beauchamp EM, Uren A.A new era for an ancient drug: arsenic trioxide and Hedgehog signaling [J].Vitamins and hormones, 2012,88:333-354.
3Chen GQ, Zhu J, Shi XG, et al. In vitro studies on celluar and molecular mechanisms of arsenic trioxide (As203) in the treatment of acute promyelocytic leukemia: As203 in- duces NB4 cell apoptosis with downregulation of Bcl-2 ex- pression and modulation of PML-RAR alpha/PML proteins [J]. Blood. 1996.88:1052-1061.
4Nakagawa Y, Akao Y, Morikaw a H, et a/.Arsenic trioxide induced apoptosis through oxidative stress in cells of co- lon cancer cell lines[Jj.Life Science, 2002,70(19) :2253.
5Soignet SL, Maslak P, Wang ZG, et al. Complete remission after treatment of acute promyelocytic leukemia with arse- nic trioxide[J].N Eng[JMed,1998,339 (19):1341- 1348.
6Berra E, PagesG, Pouyssegur J. MAP kinases and hypox- ia in the control of VE(3F expression [J]. Cancer, Me- ta-Satasis Rev,2000, 19:139-145.
7Shibuya M Differential roles of vascular endotheliar growth factor receptor-1 and receptor-2 in angiogenesis [J ]. J Biochem Mol Biol, 2006,39 (5) :469-478.
8Bussolati B, Dunk C, Grohman M, et aL Vascular endothe- lial growth factor receptor-1 modulates vascular endothe- liar growth factor-mediated angiogenesis of rheumatoid arthritis [J ].J Rheumatol, 1995,22:1624-1630.
8Clark R L,Cuttino J T Jr,Anderle S K,et al.Radiologic analysis of arthritis in rats after systemic injection of streptococcal cell walls[J].Arthritis Rheum,1979,22(1):25-35.
9Jou I M,Shiau A L,Chen S Y,et al.Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis[J].Arthritis Rheum,2005,52(1):339-344.
10Maria J,David A.Rheumatic disease and malignancy-is there anassociation[J].Scand J Rheumatol,2001,30(4):185-188.
4Stuad JM, Cremer MA, Townes AS, et al. Type 11 collagen induced arthritis in rats:passive transfer with serum and evidencethat IgG antieollagen antibodies can cause arthritis[J]. J Exp Med,1982, 155(1): 1-16.
5Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining muhipotent mesenehymal stromal cells: the International Society for Cellular Therapy position statement[J]. Cytotherapy, 2006, 8(4): 315-317.
6Naithani R, Mahapatra M, Kumar R, et al. Arsenic trioxide induced acute flare-up of rheumatoid arthritis in a patient with APL[J]. Ann Hematol, 2007, 86(2): 151-152.
7Assmann G, Koenig J, Pfreundschuh M, et al. Genetic vari- ations in genes encoding RANK, RANKL, and OPG in rheuma- toid arthritis: a case-control study[J]. J Rheumatol, 2010, 37 (5) : 900-904.