无忧汤对CUMS抑郁症大鼠模型行为学的影响研究

To research the Effect of Wu You Decoction on Behaviors of Depressed Rat Model Caused by Chronic Unpredictable Mild Stress

目的观察无忧汤对慢性不可预见性轻度应激抑郁症模型大鼠行为学的影响,了解无忧汤防治抑郁症的效果。方法将60只SD雄性大鼠随机分为6组,空白对照组、模型组、文拉法辛组、无忧汤高、中、低剂量组,联合孤养和21d慢性轻度不可预见性的应激刺激为方法进行抑郁症大鼠造模,造模成功后进行21d药物干预,灌胃给药。采用敞箱实验和蔗糖水消耗试验观察大鼠行为学变化,并进行统计分析。结果无忧汤能够明显改善抑郁模型大鼠的行为学障碍,表现为大鼠的水平及垂直运动得分均增加,蔗糖水的饮用量明显增加(P<0.05)。结论无忧汤具有防治抑郁症的效果。

Objective The present study was designed to observe the effect of Wu You Decoction on behaviors of depressed rat model caused by chronic unpredicted mild stress,to explore its effect on depression. Methods 60 male SD rats were randomly divided into six groups：the normal control group, the model group,Venlafaxine group,the high,middle and low dose of Wu You Decoction groups. Establishing the depressed rat model by solitary raise combines with chronic unpredictable mild stress 21 days, then giving the medicines 21 days orally. To observe changes of behaviors of depressed rat by open field test and sugar consumption test and analyze the results. Results Wu You Decoction can improve obviously behaviors disorder of depressed rat model, Marked by increasing the score of horizontal and vertical movement of rats and incremental sugar consumption （P〈0. 05）. Conclusion Wu You Decoction has effect of antidepressant.