甘石青黛膏对大鼠亚急性湿疹模型皮损的影响

Effects of Ganshi Qingdai Cream intervening lesions of subacute eczema model in rats

目的观察中药甘石青黛膏对大鼠亚急性湿疹模型皮损的治疗效果。方法大鼠亚急性湿疹模型造模成功后进行中药甘石青黛膏干预,并用安慰剂(白凡士林)组进行对照,观察红斑、水肿、表皮剥脱、苔藓化等症状,以湿疹面积及严重度指数评分法评价疗效。结果以湿疹面积及严重度指数评分法比较模型大鼠红斑、水肿、表皮剥脱以及苔藓化等各项数据,甘石青黛膏干预大鼠皮损与本组干预前相比,差异有统计学意义(P<0.01);甘石青黛膏组干预后与安慰剂组模拟治疗后相比差异有统计学意义(P<0.01),甘石青黛膏组症状评分均优于安慰剂组;评价两组湿疹模型干预后总体疗效,安慰剂组总有效率为42.10%,甘石青黛膏组总有效率为72.22%,经统计学处理,差异有统计学意义(P<0.05),甘石青黛膏总体疗效优于安慰组。结论中药甘石青黛膏对亚急性湿疹模型皮损具有控制红斑,消除水肿,促进破损表皮修复,抑制苔藓化的作用。

Objective To observe the therapeutic effect of Ganshi Qingdai Cream intervening le- sions of subacute eczema model in rats. Method Ganshi Qingdai Cream intervening lesions of subaeute eczema model in rats, which was to compare with placebo（ white vaseline）. The change of lesions from ery- thema, edema, skin exfoliation, and moss et al as well as eczema area, severity index score were further observed. Results Though the means of eczema area, severity index score,the effects of erythema, ede- ma, skin exfoliation, and moss from subacute eczema model of skin lesions in rats treated by Ganshi Qing- dai Cream were very good, the difference of effect after treating compared with before treating was signifi- cant （P 〈0. 01 ）. The effects of erythema, edema, skin exfoliation, and moss from eczema model of skin lesions in rats treated by Ganshi Qingdai Cream were superior to ones of placebo group （ P 〈0.01 ）. The to- tal effective rate of placebo group was 42. 10%, the total effective rate of Ganshi Qingdai Cream was 72. 22% , by statistical analysis, the total effective rate of Ganshi Qingdai Cream was better than one of pla- cebo, and the difference was significant （P 〈 0. 05 ）. Conclusion Traditional Chinese medicine Ganshi Qingdai Cream could control erythema, eliminate edema, repair the damaged epidermis, inhibit moss role of eczema model of skin lesions in rats.