女性泌尿生殖道支原体检测及耐药性分析

Analysis on detection and resistance of female urogenital mycoplasma

目的为了解泸州地区女性泌尿生殖道支原体感染及耐药情况,以指导临床合理用药。方法采用法国生物梅里埃股份有限公司IST2支原体培养及药敏配套试剂盒,对疑为支原体感染的女性患者泌尿生殖道分泌物进行支原体培养及药敏试验。结果 814例女性泌尿生殖道感染标本中,共检出支原体443例,检出率54.4%(443/814)。在阳性结果中,解脲支原体(Uu)阳性372例,阳性率84.0%(372/443);人型支原体(Mh)阳性42例,阳性率9.5%(42/443);Uu+Mh 29例,阳性率6.5%(29/443)。原始霉素、克拉霉素、强力霉素、交沙霉素、四环素对单纯Uu感染敏感性较好;原始霉素、强力霉素、交沙霉素对单纯(Mh)感染敏感性较好。结论泸州地区女性泌尿生殖道支原体感染以Uu为主,Uu感染率明显高于Mh感染及Uu+Mh混合感染。原始霉素、强力霉素、交沙霉素可作为女性泌尿生殖道支原体感染治疗的首选药物。

Objective To research female urogenital tract mycoplasma infection and drug resistance, in order to guide rational use of drug. Methods Mycoplasma stains isolated from female patients suspected mycoplasma infec- tion were cultured and sensitivity test was performed. Results Among 814 female urogenital tract infection speci- mens, there were 443 cases with mycoplasma infection, and the detection rate was 54.4% （443/814） ; 372 cases of Ureaplasma urealytium （UU） positive, and the positive rate was 84.0% （372/443） ; 42 cases of Mycoplasma homi- nis （Mh） positive, and the positive rate was 9.50/00 （42/443）; 29 cases with UU ＋ Mh infection, and the positive rate was 6.5% （29/443）. The sensitivity of pristinamycin, clarithromycin, doxycycline, josamycin, and tetracycline on simple UU infection were better. The sensitivity of pristinamycin, deoxycycline, and josamycin on simple Mh in fection were better. Conclusion The female urogenital mycoplasma infection was mainly by UU. UU infection rate was significantly higher than Mh infection and UU ＋ Mh mixed infection rate. Pristinamycin, doxycycline, and josamycin could be the first choice for treatment of female urogenital mycoplasma infection.