平均血小板体积对慢性乙肝患者肝纤维化严重程度的评价

The assessment of liver fibrosis score (LFS) in patients with chronic hepatitis using mean platelet volume

目的研究平均血小板体积(MPV)与慢性乙肝患者肝纤维化严重程度的相关性。方法 118例慢性乙肝(CHB)患者与50例对照组比较HBV-DNA水平、HBeAg(+)、肝功能试验、白细胞、血小板计数、血红蛋白、病理学活动指数(HAI)、LFS和MPV等。结果与对照组比较,CHB患者MPV显著增加接收者操作特征曲线分析显示CHB优化MPV水平临界值为8.0fL,灵敏度、特异度、阳性发生率(PPV)和阴性发生率(NPV)分别为68%,76%,86%和50%。结论 MPV有助于评估CHB纤维化程度。但不是单独的特异指标,因为与其他疾病有非特异性联系。

Objective To study the correlation of mean platelet volume（MPV） and stage of liver fibrosis in patients with chronic hepatitis B（CHB）. Methods 118 cases of chronic hepatitis B（CHB） patients and 50 cases of control group in comparison to the HBV-DNA level, HBeAg（＋）, liver function tests, white blood cell, platelet count, hemoglobin, histological activity index, LFS, MPV and so on. Results Receiver operating characteristic（ROC）curve analysis suggested that the optimum MPV level cut-off points for CHB was 8.0 fI.,with sensitivity,specificity,positive and negative predictive value of 77% ,59% ,45% ,and 85% ,respec- tively. Conclusipn MPV might help in the assessment of fibrosis in CHB. It should not be considered a stand-alone test for this use owing to nonspecificity with other diseases.