上海长宁区15306例0～2岁儿童25羟基维生素D检测值分析

Analysis of 25-hydroxyvitamin D level of 15306 children of 0-2 years old in Changning district in Shanghai

目的通过对该院儿童保健门诊15306例0～2岁儿童25羟基维生素D数值的分析,了解长宁地区儿童维生素D营养状况,为临床诊断维生素D缺乏性佝偻病提供实验室依据。方法对于2011年1月至2012年9月来该院儿童保健门诊就诊的15306例儿童进行25羟基维生素D的检测,分析25羟维生素D数值,并给予数据进行95%置信区间统计参考范围。结果 15306例0～2岁儿童25羟维生素D平均水平为(74.82±25.42)nmol/L,95%置信区间为32.48～116.52nmol/L。健康男女儿童血清25羟维生素D的平均水平分别为(74.92±25.23)nmol/L,(74.77±25.53)nmol/L,二者比较,差异有统计学意义(P<0.05)。结论长宁地区0～2岁儿童25羟维生素D数值范围低于系统给定的参考值范围;长宁地区儿童维生素D营养状况处于相对缺乏水平。

Objective To control the vitamin D level in 0-2 years old children in Changning District and to provide scientific ba- sis for the diagnosis of vitamin D deficiency rickets. Methods We detected and analyzed 25-hydroxyvitamin D level of 15 306 chil- dren came to the outpatient of Child care clinics in our hospital between Jan. 2011 and Sep. 2012,and then set up a 95 % confidence interval estimated as the parameter. Results The average of 25-hydroxyvitamin D level of 15 306 children was（74.82 ± 25.42） nmol/L, and 95% confidence interval was 32.48- 116.52 nmol/L. The serum level of 25-hydroxyvitamin D in healthy boys and girls was（74.92±25.23）nmol/L and（74.77± 25.53）nmol/L, the difference was statistically significant（P〈0.05）. Conclusion This analysis showed that the range of 25-hydroxyvitamin D of children 0-2 years old is lower than the system reference interval, which indicated the vitamin D is relatively deficient in children in Changning District.