妊娠期妇女微量元素含量分析

Analysis of serum trace elements levels in gestation

目的分析妊娠期妇女血清中微量元素钙(Ca)、镁(Mg)、磷(Pi)、铁(Fe)、锌(Zn)、铜(Cu)含量,为妊娠期妇女合理补充微量元素提供依据。方法收集该院体检妊娠期妇女352例,根据妊娠时间分为早期、中期和晚期妊娠3组,采集空腹静脉血分离血清,用日立7600全自动生化分析仪检测钙、镁、磷、铁、锌和铜含量。各组结果与健康育龄期未孕妇女对照组(139例)比较。结果妊娠各期血钙、锌、铜与对照组比较,差异有统计学意义(P<0.05)。随着孕龄增加,血锌与血钙含量逐渐降低,血铜含量逐渐增高。早期妊娠血镁与对照组差异无统计学意义(t=1.86P>0.05),与中、晚期妊娠比较,差异有统计学意义(P<0.05)。结论妊娠期合理补充、钙锌具有重要意义。血铜含量逐渐增高,补充铜不应以健康育龄期未孕妇女参考区间作为补充依据,而应以根据妊娠各期血清铜参考区间为参考补充铜。

Objective To study the levels of serum calcium,magnesium,phosphorus,ferrum,zinc and copper in pregnant women and provide useful data for reasonable trace elements supplement during pregnancy. Methods 491 pregnant women were enrolled and divided into 3 groups based on gestationat weeks,early pregnancy group,mid-term pregnancy group and late pregnancy group, serum Ca, Mg. Pi, Fe, Zn,Cu levels were detected by Modular P and compared with control group（139 healthy women of reproduc- tive age）. Results There is significant difference existed in the levels of Ca, Zn and Cu（P〈0.05）. the levels of serum zinc and calci- um decreased gradually with increasing gestational weeks, copper content increased gradually, serum magnesium level in early preg- nancy group showed no significant difference with control group（t=1.86 ,P〉0.05） and statistically significant difference with mid- term pregnancy group and late pregnancy（P〈0.05）. Conclusion It is important to take zinc and calcium supplements for pregnant women, copper content increased gradually with increasing gestational week, to take copper supplement should not base on reference interval of healthy women of reproductive age and should base on reference interval of pregnant women.