血清炎性因子与2型糖尿病患者认知功能的相关性分析

Correlation between serum inflammatory factors and cognitive function in type 2 diabetes metillus

目的探讨血清中炎性因子水平与2型糖尿病(T2DM)患者认知功能的关系。方法选择T2DM患者83例,根据简易精神状态量表(MMSE)测评分为认知正常组(39例)和认知障碍组(44例);采用全自动生化分析仪检测总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和糖化血红蛋白(HbA1c)含量,酶联免疫吸附法检测血清中IL-6、IL-8和TNF-α水平。结果 T2DM认知正常组和认知障碍组患者体质量指数(BMI)、TG、和HbA1c与对照组比较,差异有统计学意义(P<0.05);T2DM认知障碍组MMSE总分以及MMSE量表定向力、记忆力、语言能力、注意力和计算力以及视觉空间能力得分及血清中炎性因子水平明显高于对照组和T2DM认知正常组,差异有统计学意义(P<0.05)。结论血清中炎性因子IL-6、IL-8和TNF-α水平上升导致T2DM患者认知功能下降的重要因素,炎症反应可能与糖尿病认知功能障碍的发生有关。

Objective To explore the relationship between the level of inflammatory factors in serum and cognitive function in patients of type 2 diabetes mellitus（T2DM）. Methods 83 cases of patients with T2DM were selected and divided into cognitively normal group（39 cases） and cognitive impairment group（44 cases） based on the Mini-Mental State Examination（MMSE） ;the con-tent of TC,TG, HDL-C,LDL-C and HbAlc were detected using automatic biochemical analysis, and the levels of IL-6, IL-8 and TNF-α in serum were detected with enzyme-linked immunosorbent assay. Results The body mass index（BMD ,TG,and HbAlc of TZDM cognitively normal group and cognitive impairment group had statistically significant comparing with the normal control group（P〈0. 05）;The MMSE total score and disorientation, memory, language skills, attention and Computing power and visual-spatial ability score in the MMSE scale and inflammatory factors of T2DM cognitive impairment group were significantly higher than normal control group and T2DM cognitive normal group（P〈0.05）. Conclusion The rise of IL-6,IL-8 and TNF-α in serum was an important factor leading to the cognitive function＇ decline in type 2 diabetes mellitus,the inflammatory response may be re-lated to the diabetes cognitive dysfunction.