2009～2012年肠球菌属的临床分布及耐药性分析

Clinical distribution and analysis of drug resistance of Enterococcus isolated from 2009 to 2012

目的了解医院临床分离的498株肠球菌属的耐药性。方法收集该院2009年1月至2012年6月临床标本中分离出的肠球菌属(498株),对其进行系统检验,采用纸片扩散法加MIC法进行药敏试验。结果临床标本中肠球菌属在尿液中的分布最高,占72.7%;屎肠球菌与粪肠球菌对抗菌药物的耐药率不尽相同,万古霉素耐药菌株逐年增多。药敏试验结果表明,屎肠球菌的总体耐药率高于粪肠球菌;肠球菌属对四环素、青霉素G、高含量庆大霉素的耐药率较高,对万古霉素、利奈唑胺、替考拉宁保持高度敏感性。结论医院肠球菌属感染以屎肠球菌为主,粪肠球菌次之;以泌尿系统感染最为常见;耐万古霉素肠球菌株明显增加;监测肠球菌属的耐药状况对指导临床治疗具有重要意义。

Objective To investigate the drug resistance of 498 Enterococcus isolated in our hospital. Methods A total of 498 strains of Enterococcus isolated from clinical specimens from Jan 2009 to Jun 2012 were collected for systematic test, the drug sus ceptibility testing was performed by K-B disc dilution plus MIC method. Results Most of the enterococeal isolates were distributed in urine,accounting for 72.7%. There were different rates of resistance to antibiotics between Enterococcus faecium and Enterococ-cus faecalis. Enterococcal strains resistant to vaneomyein were increasing year by year. Drug resistance of Enterococcus faecium was higher than of Enterococcus faecalis. Enterococcus was resistant to Tetracycline, Penicillin G, Gentamicin （high concentration ）, but highly sensitive to Vancomycin ,Linezolid and Teicoplanin. Conclusion The main Enterococci causing infections in the hospital is Enterococcus faecium,followed by Enterococcus faecalis,moreover, Urinary system infections caused by the Enterococci are mostly eommon;Enterococcus strains resistant to Vancomycin have been obviously increasing in recent years.