2010～2012年553株铜绿假单胞菌感染分布及耐药性分析

Nosocomial infection analysis and resistance induced by Pseudomonas aeruginosa during 2010-2012

目的分析铜绿假单胞菌的临床分布及耐药性,为临床医生合理使用抗菌药物及感染控制提供依据。方法应用西门子MicroScan微生物鉴定及药敏系统对2010～2012年分离得到的铜绿假单胞菌进行细菌培养鉴定及药敏分析,应用WHO-NET5.4对数据进行分析统计。结果 553株铜绿假单胞菌主要分布在呼吸内科、ICU、神经外科;标本来源以呼吸道痰标本为主(74.32%);耐药性方面阿米卡星最低为12%,其次为妥布霉素19.1%,其余抗菌药物耐药率均超过20%,其中头孢曲松及头孢噻肟最高分别为58.6%和58.9%。结论铜绿假单胞菌分离率逐年增高,仍是医院感染的主要病原菌之一,因此要注重无菌操作,注意合理用药,减少院内感染。

Objective To analyze the clinical distribution and drug resistance of pseudornonas aeruginosa. To provide the refer-ence for rational drug use for doctors and controlling nosocomial infection. Methods Pseudornonas aeruginosa was identified by mi-croscan system. The drug susceptibility data was analyzed by WHONET 5. 4 software. Results The 553 strains pseudornonas aeruginosa were mainly distributed in the respiratory medicine, ICU and department of neurosurgery. Specimens were mainly spu-tum samples（74.32 % ）. The average resistance rate of aminoglycosides is the lowest（ 12 % ）, tobramycin is the second（ 19.1% ）, oth-ers are all higher than 20 %, among which, the CRO and CTX were higher than 55 %. Conclusion Pseudornonas aeruginosa isolation rate and the rate of drug resistance increased every year. P. aeruginosa is still one of the most important pathogenic bacterium in our hospital. It is very important to select antibiotics correctly according to the results of susceptibility tests.