氟伐他汀联合贝那普利对早期糖尿病肾病的临床疗效分析

The Clinical Efficacy Analysis of Fluvastatin Combined with Benazepril in the Treatment of Early Diabetic Nephropathy

目的:探讨早期糖尿病肾病使用氟伐他汀联合贝那普利方法的临床疗效。方法:随机选取在笔者所在医院治疗早期糖尿病肾病的患者150例,并均分为三组。氟伐他汀组50例,均单纯服用氟伐他汀;贝那普利组50例,均单纯口服贝那普利;联合组50例,同时口服此两种药物。结果:三组患者治疗前尿蛋白分泌率、C反应蛋白、血清肌酸酐比较差别无统计学意义(P>0.05),在治疗3个疗程后,联合组的尿蛋白分泌率、C反应蛋白、血清肌酸酐均明显比氟伐他汀组和贝那普利组低,差异有统计学意义(P<0.05)。结论:在早期糖尿病肾病的治疗上可以用氟伐他汀与贝那普利联合用药的方法来改善患者肾功能,且安全性很高。

Objective:To investigate the clinical efficacy of fluvastatin combined with benazepril in the treatment of early diabetic nephropathy.Methods:Randomly selected 150 cases of early diabetic nephropathy patients treated in author’s hospital,and divided them into three groups.50 patients in the fluvastatin group simply took fluvastatin,50 patients in benazepril group were treated with oral benazepril,50 patients in the combined group took the two drugs at the same time.Results:Before treatment,the difference of urinary albumin excretion rate,C-reactive protein,serum creatinine had no statistical significance(P>0.05).After three courses of treatment,the urinary albumin excretion rate,C-reactive protein,serum creatinine in combined group were significantly lower than the other two groups,the data differences had statistical significance(P<0.05).Conclusion:Fluvastatin combined with benazepril in the treatment of early diabetic nephropathy can improve renal function of patients,and have high security.