博尔纳病病毒感染与神经胶质瘤相关性研究

Study on correlation between Borna disease virus infection and neuroglioma

目的探讨博尔纳病病毒(BDV)感染与神经胶质瘤发生的可能相关性。方法用Western-blot方法,对23例神经胶质瘤患者和23例脑外伤患者血清中BDV-p24/p40特异性抗体进行检测。结果 23例神经胶质瘤患者血清中BDV-p24/p40抗体阳性4例,阳性率为17.4%;脑外伤患者血清标本中无BDV-p40抗体检出,阳性率为0%。结论神经胶质瘤患者血清中存在博尔纳病病毒的感染。

[Abstract] Objective To explore the relationship between the Borna disease virus （BDV） infection and neuroglioma. Methods BDV-p24/p40 antibodies in sera from the patients with neuroglioma and the patients with brain trauma were tested by Western-blot. Results BDV-p24 or BDV-p40 specific antibody was found in 4 cases among the 23 neuroglioma patients with the prevalence of BDV of 17.4%, and among which, 3 cases were positive of BDV-p24 antibody and 2 were positive of BDV-p40 antibody; while no BDV-p24 and BDV-p40 specific antibodies were found in the patients with brain trauma. Conclusions The findings indicate that BDV is associated with neuroglioma in some way.