2型糖尿病与非糖尿病患者非酒精性脂肪肝发病情况的临床分析

Clinical analysis on incidence of NAFL in patients with and without diabetes

目的研究2型糖尿病(T2MD)患者与非糖尿病患者非酒精性脂肪肝发病情况和特点。方法选择T2MD非酒精性脂肪肝患者50例(A组),非糖尿病非酒精性脂肪肝患者50例(B组)和健康人群50例(C组),观察分析三组人员的相关临床检测指标。结果非酒精性脂肪肝患者的体质量指数(BMI)、空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)均高于健康组(P<0.05);A组患者的FBG、TC、TG、LDL-C指标方面均显著高于B组,HDL-C、胰岛素敏感指数(HOMA-ISI)指标均明显低于B组(P<0.05)。结论糖尿病会加剧非酒精性脂肪肝病情,为了能有效预防和控制非酒精性脂肪肝,应改变饮食结构、控制体质量,加强锻炼,并做到定期体检,做到及早发现,及时诊断治疗。

Objective To study the incidence and characteristics of nonalcoholic fatty liver （NAFL） in the patients with and without type II diabetes mellitus （T2DM）. Methods Subjects consisted of 50 NAFL patients with T2DM （Group A）, 50 NAFL patients without T2DM （ Group B） and 50 healthy volunteers （ Group C）. Related clinical laboratory parameters were tested. Results The parameters such as body mass index （BMI）, fasting blood glucose （FBG）, total cholesterol （TC）, triglyceride （TG） ,low density lipoprotein-eholesterol（LDL-C） ,FINS （fasting insulin） and homeostasis model assessment of insulin resistance （HOMA-IR） were significantly higher in the NAFL patients than in the healthy volunteers （P 〈 0.05）. FBG, TC, TG and LDL-C were significantly higher and HDL-C and HOMA-ISI were significantly lower in Group A than in Group B （ P 〈 0.05 ）. Conclusion Diabetes can exacerbate NAFL. In order to effectively prevent and control NAFL, people should change in diet, control weight, do exercises and undergo regular medical examination.