三种自身抗体与复发性流产的关系研究

Relationship between three kinds of serum autoantibodies and recurrent spontaneous abortion

目的探讨封闭抗体、抗心磷脂抗体、甲状腺自身抗体与复发性流产之间的关系。方法检测50例复发性流产患者和60例正常分娩者的封闭抗体、抗心磷脂抗体、甲状腺自身抗体并对两组的封闭抗体阴性率、抗心磷脂抗体阳性率和甲状腺自身抗体阳性率进行比较。结果复发性流产组中封闭抗体阴性率为92.00%,抗心磷脂抗体阳性率为30.00%,甲状腺自身抗体阳性率TPO-AB为16%,TG-AB为14%,对照组分别为11.67%,5.00%,5.00%,3.33%,两者比较差异有统计学意义。结论患者封闭抗体、抗心磷脂抗体、甲状腺自身抗体对复发性流产的诊断具有重要的意义。

Objective To study the relationship between three kinds of antibodies, ie. blocking antibodies （ BAs）, anticardiolipin antibodies （ACAs） and thyroid antibodies, and recurrent spontaneous abortion. Methods The three kinds of antibodies were tested in 50 patients who had undergone recurrent spontaneous abortion and another 60 controls with normal deliveries. Results Nega- tive rate of BAs and positive rates of ACAs and thyroid antibodies （TPO-AB, TG-AB） were 92.00%, 30% , 16% and 14% in those with recurrent spontaneous abortion, significantly higher than that 11.67% ,5.00% ,5.00% and 3.33% of the controls （P 〈 0.05 ）. Conclusion Detection of serum autoantibodies is important in diagnosis of recurrent spontaneous aborts.