HIV阳性孕产妇母婴阻断措施的临床效果

Study on blocking measures of mother-to-child in HIV positive pregnant women

目的:探讨对HIV阳性孕产妇的新生儿予以HIV的阻断措施的临床效果。方法:设定阻断技术路线,对HIV阳性孕产妇根据孕期实施不同的阻断措施,并对采取完全阻断、不完全阻断及未采取阻断措施的新生儿HIV的阴性率进行比较分析。结果:2005年至2010年各年度有关HIV母婴阻断传播的咨询率逐年上升,HIV阳性检出率为0.3%～0.6%;共114名HIV阳性孕产妇,87例(76.3%)选择继续妊娠者中85例围生儿存活。87例中51例采用了完全阻断措施,其新生儿HIV阴性率为98.0%;29例予以不完全阻断措施,其新生儿HIV阴性率为72.4%;未采取阻断7例(1例失访),新生儿HIV阴性率为0。结论:根据孕期时间实施完全阻断措施可有效降低HIV母婴传播率,提高新生儿生存质量,对遏制婴儿和儿童人群艾滋病的传播有重要意义。

Objective： To discuss blocking effect on different blocking measures of maternal to child in HIV positive maternal neonatal. Methods： Blocking technology route was set up and different blocking measures was implemented on HIV-positive pregnant women according to the pregnancy time. HIV-negative rate of newborn who complete block, incomplete block or no preventive measures were carried out was compared and analyzed. Results： Annual consulting rate increased year by year from 2005 to 2010, HIV-positive detection rate was O. 3%-0.6 %. There were 114 cases of positive pregnant women, in which 87 cases（76.3% ） chose to continue pregnancy and 85 cases of perinatal child survival. Fifty-one cases of neonatal were given complete block measures and their HIV- negative rate was 98.0%. Twenty-nine cases of neonatal were given incomplete block measures and their HIV- negative rate was 72.4%. Seven cases of neonatal were not given preventive measures and whose negative rate was 0. Conclusion： According to the pregnancy time, implement of complete block measures can effectively reduce HIV mother-to-child transmission rate, improve neonatal survival quality, it has important significance on curb the spread of AIDS in infants and children crowd.