摘要
Three novel transition metal complexes [ML2(phen)]'H20 (M= Mn, Co, Zn; HL= C10H702NSe, 2-phenyl-4-selenazole carboxylic acid, phen= 1,10-phenanthroline) 1-3 were synthesized and characterized by elemental analysis, IR spectra. Their crystal structures were deterimined by single-crystal X-ray diffraction method. The antibacterial activities of the complexes against five species of bacteria, Escherichia coli (E. coli), Staphylococcus epidermidis (S. epidermidis), Staphylococcus aureus (S. au- reus), Acinetobacter baumanii (A. baumanii) and Streptococcus viridans (S. viridans), were tested respectively. The anticancer activities of the complexes against human pancreatic cancer line PANC-28 and human hepatocarcinoma line HuH7 were also studied. The interactions between the complexes and DNA were studied by ethidium bromide (EB) fluorescent probe.
三新奇转变金属建筑群[ML2 (phen )] ??
基金
financially supported by Natural Science Foundation of Zhejiang Province (Y4080256)