京尼平苷微囊的制备及体外评价

Preparation and in Vitro Evaluation of Geniposide Microcapsule

目的:优选制备京尼平苷微囊的工艺条件。方法:明胶为材料,采用单凝聚法,以包封率为评价指标,利用均匀设计法优选最佳的微囊制备条件。结果:囊心囊材比为1:12,温度45℃,转速为500 r.min-1。结论:微囊制备工艺稳定、粒径分布及溶出符合要求。

Objective：To study the preparation method for geniposide microcapsule using gelatin gum as sealing materialis.Methods：Geniposide microcapsule was prepared by simple coacervation method.The uniform design was adopted to optimize the preparation procedure,entrapment efficiency as evaluation indexes.Results：The optimum preparation technique of geniposide microcapsule：the ratio of core material to coating material was 1：12,the temperature of encapsulation was at 45℃ and the stirring speed was 500 r·min-1.Conclusion：The results showed that geniposide microcapsule had appropriate diameter,distribution of microcapsule particles size and dissolution as well as requirements.