安徽蚌埠地区卡波氏肉瘤相关疱疹病毒的血清阳性率研究

Seroprevalence of Kaposi’s sarcoma-associated herpesvirus in Bengbu,Anhui Province

目的研究安徽蚌埠地区卡波氏肉瘤相关疱疹病毒(KSHV)在普通人群中的感染情况,并初步分析KSHV感染的危险因子。方法选择KSHV ORF65、ORF73和K8.1编码的病毒蛋白为抗原,采用酶联免疫法对1 008份普通人群血清进行了KSHV抗体检测。结果在检测的1 008份血样中,KSHV抗体的总阳性率为4.3%,其中男为3.9%,女为4.6%。统计学分析结果显示,KSHV感染率没有性别差异,在年龄上也基本无差异。结论在中国安徽北部地区的普通人群KSHV的感染率较低,且KSHV的感染与年龄及性别之间无明显相关性。

Objective To obtain KSHV seroprevalence in the general population in Bengbu, Anhui Province. Methods Antibodies to one latent protein of KSHV （ORF73） and two KSHV lytic proteins （ORF65 and ORF- K8. 1 ） were tested by ELISA. Results Of the 1 008 subjects, the seroprevalence of KSH,V in the general population was 4. 3% and slightly higher in the female than the male （4. 6% vs 3.9% ）. Statistical analysis showed that seroprevalence of KSHV had no differences between the gender and age. Conclusion These results indicate that the infection rates of KSHV are low in north of Anhui Province. The infection of KSHV has no association with the gender and age.