女性慢性特发性荨麻疹血清脱氢表雄酮硫酸酯水平检测及意义

Analyses of serum DHEA-S and total IgE in female patients with chronic idiopathic urticaria

采用放射免疫分析法及双抗体夹心ELISA法测定80例女性慢性特发性荨麻疹(CIU)患者(CIU组)和20例女性健康对照者(健康对照组)血清中脱氢表雄酮硫酸酯(DHEA-S)及总IgE水平,并将其水平变化与病情程度和评分进行相关性分析。CIU组血清总IgE水平明显高于健康对照组(t=3.887,P<0.01)。CIU组血清DHEA-S水平低于健康对照组(t=2.431,P<0.05)。DHEA-S水平与CIU的轻、中、重度分级呈负相关(rs=-0.562,P<0.05)。CIU患者血清总IgE≥175 g/L时,其与病情分级呈正相关(rs=0.764,P<0.05),与DHEA-S水平呈负相关(rs=-0.690,P<0.05)。

The serum levels of DHEA-S were determined by radioimmunoassay and the serum total IgE was determined by sandwich ELISA in 80 patients with CIU and 20 healthy controls. The relationship between the level and the urticaria severity was compared using linear correlation. There was a significant difference in the level of the to tal IgE and DHEA-S in two groups, and the level of the serum total IgE was higher in the patients than that in health controls（t =3. 887, P 〈0.01 ）, and the level of serum DHEA-S in the former was lower than that in the latter（ t = 2. 431, P 〈 0.05 ）. The serum DHEA-S was positively correlated with the disease classification, and the serum total IgE was also positively correlated with the disease classification and was negatively correlated with the lev- el of DHEA-S, up to≥175 g/L（P 〈0.05）.