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微小RNA在糖尿病及其并发症中的分子机制 被引量：2

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摘要 微小RNA(miRNA)是非编码基因的产物,可通过与mRNA特异结合来调节基因的表达。在糖尿病领域,已发现多种miRNA可通过调节胰岛素分泌、胰腺的分化发育、胰岛细胞脂性凋亡及胰岛素敏感性来影响糖尿病的发生发展,且在相关并发症的发病机制中发挥重要作用,本文综述糖尿病及其并发症发病机制相关的miRNA研究的最新进展。
作者 徐淼 魏丽
机构地区 上海交通大学附属第六人民医院内分泌代谢科
出处 《江苏医药》 CAS 北大核心 2013年第8期955-957,共3页 Jiangsu Medical Journal
基金 国家自然科学基金(30670989) 上海市糖尿病重点实验室项目(08DZ2230200)
关键词 相关并发症 糖尿病 微小RNA 分子机制 MIRNA 胰岛素敏感性 调节基因 发病机制
分类号 R587 [医药卫生—内分泌]
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参考文献22

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同被引文献18

  • 1杨慧霞.妊娠合并糖尿病临床诊断与治疗推荐指南(草案)[J].中国实用妇科与产科杂志,2007,23(6):475-477. 被引量：369
  • 2Khavandi K,Amer H,Ibrahim B,et al.Strategies for preventing type 2 diabetes: an update for clinicians.Ther Adv Chronic Dis,2013,4(5):242-261,.
  • 3MM Martin,EJ Lee,JA Buckenberger, et al.MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts.J Biol Chem. 2006,281: 18277-18284.
  • 4Corral-Fernandez NE,Salgado-Bustamante M,Mart i nez-Leija ME,et al.Dysregulated miR-155 expression in peripheral blood mononuclear cells from patients with type 2diabetes.Exp Clin Endocrinol Diabetes,2013,121(6):347-353.
  • 5Lovis P,Roggli E,Laybutt DR,et al.Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes,2008,5 7 (10) :2 7 28- 2 7 36.
  • 6Balasubramanyam M,Aravind S,Gokulakrishnan K,et al.lmpaired miR- 146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes.Mol Cell Biochem,2011,351 (1-2): 197-205.
  • 7Kilikian BV,Afonso LC,Souza TF. Filamentous fungi and media for cellulase production in solid state cultures[J].BRAZILIAN JOURNAL OF MICROBIOLOGY,2014,(01):279-286.
  • 8Zhao C,Zhang T,Shi Z. MicroRNA-518d regulates PPARα protein expression in the placentas of females with gestational diabetes mellitus[J].Mol Med Rep,2014,(06):2085-2090.
  • 9Shi Z,Zhao C,Guo X. Differential expression of microRNAs in omental adipose tissue from gestational diabetes mellitus subjects reveals miR-222 as a regulator of ERα expression in estrogen-induced insulin resistance[J].ENDOCRINOLOGY,2014,(05):1982-1890.
  • 10Bari MF,Weickert MO,Sivakumar K. Elevated Soluble CD163 in Gestational Diabetes Mellitus:Secretion from Human Placenta and Adipose Tissue[J].PLoS One,2014,(07):e101327.

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江苏医药
2013年 第8期

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