博卡病毒属基因组特征与致病的分子机制

Genomic characteristics of bocavirus and molecular mechanism of its pathogenicity—A review

博卡病毒是细小病毒科细小病毒亚科的成员之一。目前已知博卡病毒成员有牛博卡病毒、犬博卡病毒、人博卡病毒、以及新鉴定的猪博卡病毒,猩猩、猫、犬以及加利福尼亚海狮体内发现的新博卡病毒成员。作为新发病原,博卡病毒成为各国科研人员的研究热点。本文结合前人的文献和我们近期的研究成果,对博卡病毒的家族成员分类、基因组结构与复制、临床致病特点、致病分子机制等方面进行了阐述,为广大科研人员对博卡病毒的研究提供一定的帮助。

Bocavirus was considered as a member of the subfamily parvoviriae of the family parvoviridae, which includes bovine bocavirus, minute virus of canines, human bocavirus, as well as the newly identified swine bocavirus, gorilla bocavirus, feline boeavirus, canine bocavirus and bocavirus identified in California sea lion sample. At present, as an emerging pathogen, bocavirus members attract great attention by researchers worldwide. We reviewed published papers in combination with our study for several aspects of bocavirus family including their classification, genome structure and replication, clinical pathogenic characteristics and molecular pathogenesis.