摘要
微透析能在微创的前提下进行取样,具有在体、实时、多位点取样和在线分析等优点。在皮肤给药系统研究中,特别是在药动学以及药效学研究中优势显著,具有很好的应用前景。本文对微透析技术在皮肤给药药动学、药效学研究中的应用作一综述。
Microdialysis has many advantages, such as minimal invasion, in- vivo, real- time, muhisites sampling and on-line analysis. The advancement of microdialysis in cutaneous drug administration has a wide range of application prospect, especially in pharmacokinetics and pharmacodynamics. Microdialysis technology used in pharmacokinetics and pharmacodynamics studies after cutaneous drug administration was reviewed in this article.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2013年第4期272-276,共5页
Chinese Journal of New Drugs and Clinical Remedies
基金
浙江省中医局项目(2010ZA013)
浙江省医学重点学科群项目(XKQ-010-001)
浙江省科技计划项目(2011F10048)
关键词
微透析
投药
皮肤
药动学
药效学
microdialysis
administration, cutaneous
pharmacokinetics
pharmacodynamics
