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Clusterin在恶性肿瘤治疗中的研究进展 被引量：5

Advances in research on the role of clusterin in treatment of human malignancies
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摘要 CLU(Clusterin)是一种广泛存在于人体组织和体液中的凋亡相关蛋白,在多种病理、生理过程(包括组织重构、再生、脂质转运、补体调节和细胞凋亡等)中发挥重要作用。研究发现,CLU在正常的成熟组织中低表达,而选择性地在某些恶性肿瘤中高表达。CLU有2种主要亚型:分泌型CLU和核型CLU,它们在人类恶性肿瘤中发挥不同的作用。在恶性肿瘤治疗中,以CLU为靶点的研究已逐步展开。 CLU （Clusterin） is an apoptosis-related protein which widely exists in human tissues and body fluids. It plays an important role in various pathophysiological processes including tissue remodeling, reproduction, lipid transport, complement regulation, and apoptosis. It was reported that CLU exerts a low expression level in normal and mature tissues while a high expression level in certain malignant tumors. CLU appears to have two main isoforms including secreted form and nuclear form. These two isoforms of CLU play different roles in human malignancies. Currently, more studies focused on treatment targeting CLU are going on.
作者 马晓 李鹤成
机构地区 复旦大学附属肿瘤医院胸外科
出处 《肿瘤》 CAS CSCD 北大核心 2013年第4期368-371,共4页 Tumor
基金 上海市青年科技启明星计划(跟踪)(编号:11QH1400600) 国家自然科学基金资助项目(编号:81272608)
关键词 肿瘤 治疗 凋亡调节蛋白质类 CLUSTERIN Neoplasms Therapy Apoptosis regulatory proteins Clusterin
分类号 R730.5 [医药卫生—肿瘤]
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参考文献3

二级参考文献23

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  • 4BETTUZZI S, SCORCIONI F, ASTANCOLLE S, et al. Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression [ J ]. Oncogene, 2002 , 21 ( 27 ) :4328-4334.
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共引文献7

同被引文献29

  • 1翁锡全,余群,林文弢,徐国琴,黄利军,李良鸣,王玉昕.低氧暴露对运动诱导的血红蛋白低下大鼠红细胞参数和某些造血因子的影响[J].中国运动医学杂志,2006,25(5):538-542. 被引量：13
  • 2李鹤成,相加庆,张亚伟.抗clusterin反义核酸治疗提高肺癌H460细胞放射敏感性的实验研究[J].肿瘤,2007,27(1):22-25. 被引量：3
  • 3JEMAL A, BRAY F, CENTER M M, et al. Global cancerstatistics [ J ] . CA Cancer J Clin, 2011, 61(2): 69-90.
  • 4KAMIHIRA S, YAMADA Y, HIRAKATA Y, et al. Aberrant expression of caspase cascade regulatory genes in adult T-cell leukaemia: survival is an important determinant for prognosis [ J ] . Sr J naematol, 2001, 114(1): 63-69.
  • 5LAKINS J, BENNETT S, CHEN J, et al. Clusterin biogenesis is altered during apoptosis in the regressing rat ventral prostate [ J ]. J Biol Chem, 1998, 273(43): 27887-27895.
  • 6YANG C R, LESKOV K, HOSLEY-EBERLEIN K, et al. Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death [J] . Proc Natl Acad Sci U S A, 2000, 97(11): 5907-5912.
  • 7O'SULLIVAN J, WHYTE L, DRAKE J, et al. Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis [ J ] . Cell Death Differ, 2003, 10(8): 914-927.
  • 8SONN C H, YU Y B,YONG Y J, et al. Clusterin synergizes with IL-2 for the expansion and IFN- ~/ production of natural killer cells [J]. J Leukoc Biol, 2010, 88(5): 955-963.
  • 9BETTUZZI S, SCORCIONI F, ASTANCOLLE S, et al. Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression [ J ] . Oncogene, 2002, 27(21): 4328-4334.
  • 10MATSUDA A, ITOH Y, KOSHIKAWA N, et al. Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils [ J ] . J Biol Chem, 2003, 278(38): 36350-36357.

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肿瘤
2013年 第4期

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