烧伤脓毒症诊断与综合防治策略

Diagnosis and comprehensive management of sepsis after burn

脓毒症是指由感染诱发的全身炎症反应综合征（SIRS），是严重烧伤后常见的并发症和死亡原因之一，进一步发展可导致脓毒性休克、MODS等，是危重烧伤临床救治的难点和重点。

Sepsis induced by invasive infection is a challenging problem and the major cause of death after severe burn. With the increasing understanding of sepsis, diagnostic criteria of sepsis were proposed and revised consecutively so that they could be consistent with the clinical practice. Being different from other trauma and critical diseases, diagnostic criteria of sepsis after severe burn were also proposed, and they need further clinical verification. It is believed that comprehensive meas- ures for the treatment of severe sepsis after burn should be advocated. These measures include rapid and effective resuscitation of burn shock, early escharectomy and closure of burn wound, metabolic support, immunoregulation and anti-inflammation, reinforcement of organ support, etc. Although a number of ad- vances have been achieved in the past decades, the mechanism of sepsis need further elucidation, diagnostic criteria of sepsis need further revision, and novel therapeutic measures for burn sepsis should be developed.