JAK/STAT信号通路在动脉粥样硬化中的作用

Effect of JAK/STAT pathway in atherosclerosis

动脉粥样硬化(AS)是一种慢性炎症疾病,包含血管细胞和炎症细胞之间复杂的相互作用。酪氨酸激酶/信号转导子和转录激活子(JAK/STAT)信号通路是多种细胞因子和生长因子在细胞内传递信号的共同途径,参与机体免疫反应、血管细胞迁移增殖和凋亡等多种生物学活动。文章对目前JAK/STAT信号通路在AS发生和发展中的作用进行了综述。

Atherosclerosis is a chronic inflammatory disease including complex interactions between vascular cells and inflammatory cells. Janus kinase/signal transducer and activator of transcription（JAK/STAT） pathway acts as a common intracellular transduction pathway of various of eytokines and growth factors, which involves in many biological activities such as immunological response and growth, migration and apoptosis of vascular cells. The effects of JAK/STAT pathway on the development and progression of atheroselerosis are reviewed in this paper.