妊娠梅毒与先天梅毒

Syphilis in pregancy and congenital syphilis

近十年来妊娠梅毒和先天梅毒的发病率呈上升趋势。未经治疗的孕妇可将梅毒传染给胎儿，引起生长受限、肝肿大、血液与转氨酶异常，进而导致早产、死产、先天梅毒。早期先天梅毒以皮肤、脏器炎症反应为主；晚期先天梅毒，主要是慢性炎症导致的畸形。对妊娠梅毒患者的及时诊断和治疗可有效避免先天梅毒的发生。此文对妊娠梅毒和先天梅毒的临床特征、诊断、治疗及随访做一综述，以期为临床工作提供参考。

Morbidity of syphilis in pregnancy and congenital syphilis has been rising during file past ten years. Untreated syphilis infection can infect fetus and leads to adverse pregnancy outcomes, including growth restriction, hepatomegaly, blood and tmnsaminase disorder, and then premature birth, stillbirth and congenital syphilis. Early con- genital syphilis presents with cutaneous covering and organ infltarmnatory re.action. Late congenital syphilis presents with anisotrophy causing by chronic inflammation. Timely diagnosis and treatment syphilis in pregnancy can avoid the incidence of congenital syphihs. The clinical characters, diagnosis, treatment and follow-up visit of syphilis in pregnancy and con- genital syphilis are reviewed in this article, so as to provide reference for clinical practice.