肿瘤坏死因子-α基因G308A多态性与结直肠癌发病风险Meta分析

TNF-α G308A polymorphism and colorectal cancer risk:a Meta-analysis

目的:评价肿瘤坏死因子-α基因G308A多态性位点对于结直肠癌患病风险的影响。方法:以"TNF-α-308、pol-ymorphism和colorectal cancer"作为检索词,检索2000-01-01-2011-09-01PubMed和Embase数据库中所有相关文献,提取其中数据进行统计分析,以比值比(OR)和95%可信区间(95%CI)评价该位点与结直肠癌易感性的关系。结果:最终筛选出9项关于该位点的研究,其中共包含了1 708例结直肠癌病例和1 754名对照。结果显示,A等位基因和G等位基因对于结直肠癌的患病风险差异无统计学意义,OR=1.89,95%CI为0.94～3.78;各种基因模式的对比也无阳性结果,GA对比GG,OR=1.16,95%CI为0.84～1.59,AA/GA对比GG,OR=1.26,95%CI为0.90～1.77,AA对比GA/GG,OR=1.75,95%CI为0.94～3.23。人种与对照来源进行的亚组分析中,也未发现有阳性结果。结论:肿瘤坏死因子-α基因G308A多态性可能对结直肠癌易感性无影响。建议今后应纳入更多的研究证据来明确该多态性位点与结直肠癌易感性的关系。

OBJECTIVE：To estimate the effect of the G308A gene polymorphism on colorectal cancer （CRC） risk. METHODS：All of the eligible studies on PubMed and Embase database were searched,extracted data from 2000-01-01 to 2011-09-01 with ＂TNF-a-308＂,＂polymorphism＂ and ＂colorectal cancer＂ as the key words,and the odds ratios （OR） with 95% confidence intervals （95%CI） was used to assess the strength of the association. RESULTS： Nine studies on the TNF-α -308 G〉A polymorphism were collected,including 1 708 CRC cases and 1 754 controls. Overall significant CRC risk were not found for A allele versus G allele （OR= 1.89,95%CI：0.94-3. ？8）,GA versus GG （OR= 1. 16,95%CI： 0. 84-1. 59）,AA/GA versus GG （OR=1. 26,95%CI：0.90-1.77）,and AA versus GA/GG （OR： 1.75,95%CI：0.94- 3.23）. In the subgroup analysis by ethnicity and by source of controls,no significantly increased risks were observed ei- ther. CONCLUSIONS： The results indicate that the TNF-α -308 G〉A polymorphism may not contribute to the risk of CRC. More studies and stringent inclusion criteria to estimate the effect of this polyrnorphism on CRC risk are needed.