SD大鼠主要脏器间的相关性分析

Correlation between main viscera in SD rats

目的测定成年SD大鼠体重与各脏器重量,并对不同脏器之间及体重与各脏器重量的相关性进行分析。方法选用三月龄SD大鼠雄性共24只,进行人道处死,解剖后分别测定心、肝、肺、肾等脏器重量,并作相关性分析。结果 SD大鼠的心、肝、肺、脾、肾与胃空体的相关性分析中,SD大鼠的心脏及肝脏重量之间不相关(P>0.05),且分别与其他各脏器及胃空体之间也无明显相关(P>0.05);而脾脏的重量与肾脏重量之间则相关极为显著(P<0.01);胃空体与肺、脾呈现极显著相关(P<0.01),与肾脏呈显著相关(P<0.05)。结论通过解剖比较SD大鼠各脏器之间的关系,对动物体内各脏器的大小及相互关系有了初步的认知,为今后进行的动物相关实验研究打下基础。

Objective Sprague-Dawlcy rat is a common experiment animal used in clinic iatrology. In this study, we investigated the weight correlation among the main viscera of 24 SD rats. Methods 24 common male SD rats （90 days old） were chosen, the body weight and 6 organ weights were determined, and the organ correlation coefficient were calcu- lated using SPSS 17.0 software. Result The result showed that there were no significant correlations （ P 〉 0.05 ） between liver and heart, and also no significant correlation with other main viscera such as lung, spleen, kidney and stomach, etc, while spleen had a distinct correlation with kidney （P 〈 0.01 ） , stomach not only had a distinct correlation with lung and spleen （ P 〈 0.01 ） but also had a significant correlation with kidney （ P 〈 0. 05 ）. Conclusions Differences of organ coef- ficients are not significant between liver and heart, while the spleen and kidney have a linear relationship. The above data could be useful in biomedical researches.