多形性胶质母细胞瘤患者高迁移率蛋白A1表达与复发时间的关系

Relationship between the expression of high mobility group A1 and time to recurrence in patients with glioblastoma multiforme

目的探讨原发与复发的多形性胶质母细胞瘤(GBM)中高迁移率蛋白A1(HMGA1)表达的差异,以及HM GA1表达失调在GBM恶化过程中的作用。方法应用免疫组织化学法比较、评估同一患者(n=19)的原发和复发GBM组织中HMGA1的表达,同时分析HMGA1表达与病情无恶化生存时间(PFST)之间的关系。结果原发和复发GBM中HMGA1的表达具有统计学差异(P=0.036),HMGA1高表达的患者的PFST明显缩短(6.1个月vs 11.5个月,P=0.030)。结论复发的GBM中HMGA1高表达,GBM患者PFST缩短与HMGA1的超表达有相关性。结果提示HMGA1可能在GBM的治疗中起重要作用。

Objective To explore the difference in the expression of high mobility group （ HMGA1 ） between primary and recurrent glioblastoma multiforme （GBM） tissues, and to determine whether the dysregulated expression of HM- GA1 plays a role in the malignant progression of GBM. Methods Paired primary and recurrent GBM specimens ob- tained from the same patient（n = 19） were evaluated by immunohistochemical studies. The association between HM- GA1 expression and progression-free survival time （PFST） was analyzed. Results There was a significant difference in HMGA1 expression between primary and recurrent tumors （ P = 0. 036）, and patients with tumors expressing HM- GA1 at a higher level had a significantly shorter PFST （6.1 months vs. 11.5 months, P = 0. 030）. Conclusion Our study indicates that HMGA1 is expressed at a high level in recurrent GBM and HMGA1 overexpression is associated with shorter PFST in patients with GBM. These findings suggest that HMGA1 potentially has an important role in the treatment of GBM.