摘要
目的观察三种不同血液净化方式[血液透析(HD)、血液透析滤过(HDF)、血液透析+血液灌流(HD+HP)]对维持性血液透析患者高磷血症清除效果。方法选择2009年2月-2011年2月行维持性血液透析的48例高磷血症患者为研究对象,所有患者在低钙透析(1.25 mmol/L)的基础,随机分为HD组、HDF组、HD+HP组,每组16例,分别在治疗时及治疗后4周、8周检查钙、磷、钙磷乘积和全段甲状旁腺激素,并观察其变化。结果在治疗4周、8周后,HDF组、HD+HP组磷较前均显著下降(P值均<0.05),两组同时点相比较差异无统计学意义(P>0.05);HD组较前血磷无明显变化(P>0.05)。结论 HDF、HP清除维持性血液透析患者高磷有显著的效果,而HD效果则不佳。
Objective To study the effect of three different modes of blood purification (HD: hemodialysis, HDF: hemodiafiltration, and HD+HP: hemodialysis and hemoperfusion) for clearance of serum phosphate in maintenance hemodialysis patients. Methods Fourty-eight patients with hyperphosphatemia undergoing maintenance hemodialysis in our department between February 2009 and February 2011 were recruited in our study. They were divided into three groups: HD group, HDF group, and HD+HP group with 16 patients in each. Serum levels of calcium, phosphate, intact parathyroid hormone (iPTH) and calcium-phosphate product were measured and analyzed before and four, eight weeks after the therapy. Results Four and eight weeks after the therapy, concentrations of Ca, Pi, iPTH and Ca^Pi in HI) group did not obviously change (P 〉 0.05), but levels of Pi, iPTH and CaxPi in HDF group and HD+HP group significantly decreased compared with those before therapy (P 〈 0.05, P 〈 0.01), except for Ca (P 〉 0.05). At the same time, difference was not detected between HDF and HD+HP groups (P 〉 0.05). Conclusion HDF and HP can effectively eliminate serum phosphate in maintenance hemodialysis patients, but HD has poor effect.
出处
《华西医学》
CAS
2013年第4期495-498,共4页
West China Medical Journal