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脑干胶质瘤的干细胞研究进展

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摘要 脑干胶质瘤是威胁人类健康的重要疾病,尤其是弥漫内生性桥脑胶质瘤,对儿童的影响更是致命性的。脑干胶质瘤占儿童后颅窝肿瘤的30%,而弥漫内生性桥脑胶质瘤占儿童脑肿瘤15%左右。后者其中位生存时间几乎不超过1年。由于过去在其生物学特性等方面研究欠缺导致此类肿瘤的治疗几乎无实质性进展。但随着近年脑干胶质瘤干细胞及其相关信号通路、细胞因子等方面的基础研究兴起,治疗方面取得了一定的成绩。在此,我们将就近几年在弥漫内生性桥脑胶质瘤基础方面的研究进展作相关综述及讨论。
作者 杨翔 张跃康
出处 《华西医学》 CAS 2013年第4期627-630,共4页 West China Medical Journal
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  • 1Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells[J]. Nature, 2001, 414(6859) : 105-111.
  • 2Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice[J]. Nature, 1994, 367(6464): 645-648.
  • 3Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells[J]. Nature, 2004, 432(7015): 396-401.
  • 4Lee J, Kotliarova S, Kotliarov Y, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines[J]. Cancer Cell, 2006, 9(5): 391-403.
  • 5Nicolis SK. Cancer stem cells and “stemness” genes in neuro-oncology[J]. Neurobiol Dis, 2007, 25(2): 217-229.
  • 6Zhang XP, Zheng G, Zou L, et al. Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells[J]. Mol Cell Biochem, 2008, 307(1-2): 101-108.
  • 7Fan X, Matsui W, Khaki L, et al. Notch Pathway Inhibition Depletes Stem-like Cells and Blocks Engraftment in Embryonal Brain Tumors[J]. Cancer Res , 2006, 66(15): 7445-7452 .
  • 8Diamandis P, Wildenhain J, Clarke ID, et al. Chemical genetics reveals a complex functional ground state of neural stem cells[J]. Nat Chem Biol, 2007, 3(5): 268-273.
  • 9Singh SK, Clarke ID, Hide T, et al. Cancer stem cells in nervous system tumors[J]. Oncogene, 2004, 23(43): 7267-7273.
  • 10Yang ZJ, Ellis T, Markant SL, et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells[J]. Cancer Cell, 2008, 14(2): 135-145.

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