喉鳞状细胞癌的表观遗传学研究进展

Alterations of Epigenetic Dysregulation in Laryngeal Squamous Cell Carcinoma

喉癌是来源于喉粘膜上皮组织的恶性肿瘤。尽管临床应用喉癌分子标记物筛查已取得重要进展,但迄今特异性标记物在喉癌筛查及随访治疗方面仍差强人意。近年来表观遗传学在恶性肿瘤生物学行为研究领域方兴未艾。表观遗传学改变涉及基因失调,主要的表观遗传学改变包括DNA甲基化失衡,组蛋白修饰和smallRNA失调。总的表观遗传学改变已被认为是恶性肿瘤的一种分子特征,而基于具体的表观遗传学模式,可确定癌症的行为和特征。本文综述了喉癌的表观遗传学改变,这对于更深入的认识与了解喉癌在表观遗传学水平上的发生和发展,促进相关成果临床应用转化具有重要意义。

Laryngeal carcinoma is a common head and neck cancer with poor prognosis. Despite the advance in the use of molecular markers for monitoring human cancers in the past decades, there are still no reliable markers for use to screen laryngeal carcinoma and follow the patients after treatment. Epigenetics emerged as an important ？ eld in understanding the biology of the human malignancies. Epigenetic alterations refer to the dysregulation of gene, including methylation imbalance, histone modi？ cation, and small RNA dysregulation could play a role in the development of humanmalignancies. Global epigenetic change is now regarded as amolecular signature of cancer. The characteristics and behavior of a cancer could be predicted based on the speci？ c epigenetic pattern. We here provide a review on the understanding of epigenetic dysregulation in laryngeal carcinoma. Further knowledge on the initiation and progression of laryngeal carcinoma at epigenetic level could promote the translation of the knowledge to clinical use.