人参防治帕金森病的研究进展

Research Advances in Using Ginseng to Prevent and Treat Parkinson’s Disease

归纳总结了帕金森病(Parkinson’s disease,PD)的研究概况、人参防治帕金森病的药理作用及其有效成分人参皂苷在保护黑质多巴胺能神经元方面相关作用机制的研究进展,为人参在防治帕金森病方面的合理应用奠定了基础。人参皂苷可能通过拮抗氧化应激反应、抑制钙通道和阻断引起神经元凋亡的多条信号通路等机制,保护多巴胺能神经元。

The current research in Parkinson＇s disease and progress in using of ginseng to treat Parkinson＇s disease, and mechanisms of ginsenosides-induced protection of dopaminergic neurons in substantia nigra were reviewed, which lay a foundation for the reasonable application of ginseng in the treatment of Parkinson＇s disease. Ginsenosides can play an important role in protecting dopaminergic neurons by countering oxidative stress, inhibiting Ca^2＋ channel and blocking the signaling pathways of neurons apoptosis.