糖尿病与非糖尿病之间的AGE激化对内皮功能的比较

Comparisons between diabetic and non-diabetic subjects ’ endothelial function after advanced glycation end products(AGE) stimulated

目的本文试图通过糖化终末产物(AGE)饮食的急性刺激观察糖尿病和非糖尿患者的内皮功能变化。方法在所有被观察的对象中在摄取富含AGE饮食前后测定上臂动脉血流量介导性扩张(FMD)和血清的AGE、纤溶酶原激活物1(PAI-1)和血管细胞黏附分子1(VCAM-1)。结果与非糖尿病组比较,糖尿病组在摄取富含AGE饮食90分钟后的AGE、PAI-1和VCAM-1均较基线值有明显升高,FMD较基线值下降。虽然在健康组中各项参数均有所改变,但未达到统计学的意义。结论尽管在健康组中的改变未能达到统计学意义,但长期在一种高AGE饮食情况下也可加速血管病变。

Objective This study was designed to test the acute effects of dietary advanced glycation end products （AGE） on endothelial function of diabetic and non-diabetic subjects. Method Flow-mediated dilation （FMD） of the brachial artery and serum level of AGEs, plasminogen activator 1 （ PAI-1 ）, and vascular cell adhesion molecule 1 （ VCAM-1 ） were assessed before and after ingestion of high rich-AGE meal in all subjects. Result The diabetic patients had higher baseline levels of serum AGEs, PAI-1, and VCAM-1 and lower baseline values of FMD compared with non-diabetic subjects. In diabetic subjects, however, after ingestion of high rich-AGE meal 90 minutes, the level of serum AGEs, PAI-1, and VCAM-1 were increased and the FMD was decreased. But in non-diabetic subjects all parameters did not change in statistical analysis, although the AGEs, PAI-1, and VCAM-lwere increased and FMD was decreased. Conclusion Significant increases in serum AGEs can occur together with altered clinical measures of endothelial function in and non-diabetic subjects after ingestion of high rich-AGE meal. Thus, repeated or chronic exposure to high AGE diet could over time lead to and/or accelerate vascular disease.