摘要
目的采用偱证医学Meta分析的方法以探讨术前肝动脉栓塞化疗对可切除肝细胞癌患者预后的影响。方法计算机检索相关数据库,全面收集有关术前肝动脉栓塞化疗对可切除肝细胞癌患者预后影响的随机对照试验,汇总数据采用RevMan5.1.6进行分析,两组之间差异采用危险比(HR)或优势比(OR)及其95%可信区间(95%CI)描述。结果严格根据纳入和排除标准,最终纳入3个随机对照试验,包括257例可切除肝细胞癌患者,其中观察组126例,对照组131例。Meta分析结果表明,两组之间5年总生存率(HR=0.73,95%CI=0.23～2.34,P=0.60)和无疾病生存率(HR=1.08,95%CI=0.66～1.77,P=0.77)无显著统计学差异。结论现有证据表明,术前TACE对可切除HCC患者的5年总生存率和无疾病生存率无明显改善。由于纳入研究质量及数量有限,本研究结论尚需大样本高质量随机对照试验进行证实。
Objective This study aims to investigate the influence of TACE on the prognosis for patients with resectable liver cancer by conducted a meta-analysis. Methods Computer retrieval relevant database, A comprehensive collection of randomized controlled trial about the influence of TACE on the prognosis for patients with resectable liver cancer. Data were analyzed by RevMan 5.1.6 software. The differences between two groups were described as Hazard Ratio （HR） or odds ratio （OR） with 95% confidence intervals （CI）. Result Finally, a total of 3 clinical controlled trials, including 257 patients with resectable HCC patients, 126 patients in psychological intervention group and 131 patients in control group. Meta-analysis showed that there were no significant differences between two groups, including total survival for 5 years （ HR = 0. 73, 95% CI = 0. 23 - 2. 34, P = 0. 60） and the disease-free survival （ HR = 1.08, 95% CI = 0. 66 - 1.77, P = 0. 77）. Conclusion The present data suggests that there is no ob- vious improvement between the total survival for 5 years and the disease-free survival of preoperative TACE for resectable HCC patients. Further well-designed randomized controlled trials are needed to confirm or adjust current conclusions.
出处
《中国老年保健医学》
2013年第2期34-36,共3页
Chinese Journal of Geriatric Care
