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有核红细胞预测缺氧缺血性脑病严重程度和预后的价值 被引量：7

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摘要 目的 调查末梢血有核红细胞（nucleated red blood cell,NRBC）计数的变化与新生儿缺氧缺血性脑病（hypoxic-ischemic encephalopathy,HIE）分型及其预后的关系,以探讨其对早期判断HIE预后的价值.方法 显微镜下计数135例新生HIE患儿和95例正常对照儿生后24h内末梢血NRBC计数,并对HIE患儿在2岁时做了详细的神经系统检查和智力发育评估.结果 中、重度HIE组NRBC计数[（16.5±2.9）NRBC/100 WBC,（30.4±4.6）NRBC/100 WBC]较轻度组[（9.4±2.4）NRBC/100 WBC]和对照组[（3.2±1.2）NRBC/100 WBC]显著增加（P＜0.05）,轻度组与对照组比较差异无统计学意义（P＞0.05）,但病情愈重,NRBC计数越高.在2岁时随访,135例HIE患儿中11例失访,52例轻度HIE患儿预后均正常,45例中度HIE患儿中15例预后异常（33.3％）,27例重度HIE患儿预后均异常.预后异常组NRBC计数[（25.7±2.5）NRBC/100 WBC,n=42]明显高于预后正常组[（12.6 ±2.0）NRBC/100 WBC,n=82],差异有统计学意义（P＜0.05）.结论 出生后24 h内NRBC计数值越高,HIE严重程度越重,预后越差.
作者 孟淑英 张可冰
机构地区 中国医科大学本溪中心医院儿科
出处 《中国小儿急救医学》 CAS 2013年第2期186-187,共2页 Chinese Pediatric Emergency Medicine
关键词 窒息 脑损伤 预后 有核红细胞 婴儿 新生
分类号 R742 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献8

  • 1谢露,陈洪清,杨尧,郑天,尹晓娟.有核红细胞预测围产期窒息严重度和短期预后的价值[J].中华临床医师杂志（电子版）,2011,5(23):7140-7143. 被引量：11
  • 2赵德才,季成叶,孙军玲,李勇.应用丹佛发育筛查法评价婴幼儿发育状况[J].中国公共卫生,2004,20(8):909-910. 被引量：12
  • 3Haiju Z, Suyuan H, Xiufang F, et al. The combined detection of umbilical cord nucleated red blood cells and lactate:early predic- tion of neonatal hypoxic-ischemic encephalopathy. J Perinat Med, 2008,36 ( 3 ) : 240-247.
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  • 7孟淑珍,韩晓华,韩玉昆.新生儿缺氧缺血性脑病患儿远期发育预后[J].中国优生优育（1990-2002上半年）,1995,6(4):170-172. 被引量：1
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二级参考文献14

  • 1Hermansen MC.Nucleated red blood cells in the fetus and newborn. Archives of Disease in Childhood . 2001
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  • 3Ferber A,Fridel Z,Weissmann-Brenner A,et al.Are elevated fetal nucleated red blood cell counts an indirect reflection of enhanced erythropoietinactivity?. American Journal of Obstetrics and Gynecology . 2004
  • 4Walsh BH,Boylan GB,Murray DM.Nucleated red blood cells and early EEG:predicting Sarnat stage and two year outcome. Early Human Development . 2011
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共引文献20

同被引文献52

引证文献7

二级引证文献61

中国小儿急救医学
2013年 第2期

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