microRNA在脓毒症患儿线粒体功能障碍的研究进展

Research progress of microRNA in mitochondrial dysfunction of children with sepsis

脓毒症是各种病原微生物及免疫原性物质引起的全身炎性反应和宿主自身免疫性损伤，进一步发展可致多器官功能障碍综合征。线粒体是细胞中重要的细胞器，通过氧化磷酸化反应为机体提供ATP，对机体生长、代谢、疾病的发生发展等多方面都有重要意义。关于脓毒症的研究在过去的几十年取得了巨大进展。大量研究表明，线粒体功能障碍程度与脓毒症的预后密切相关。microRNA是一类内源性非编码小分子RNA，在基因转录后水平调控基因和生物蛋白表达，进而调节线粒体的生物功能和氧化应激作用，对脓毒症的进程和预后有重要影响。现对microRNA在脓毒症线粒体功能障碍的相关研究作一综述。

Sepsis is the systemic inflammatory respond syndrome and autoimmunity injury caused by pathogen- ic microorganism or any other immunogenieity. Mitoehondria, an important organelle, which has an essential role in cel- lular growth, metabolism, occurrence and development of disease by generating ATP following the oxidative phosphory- lation from glycolysis. There had been some progresses on the research of sepsis in several decades, A number of studies had shown that the degree of mitochondrial dysfunction was related to the eventual outcome of sepsis, microRNA are en- dogenous small noncoding RNAs that post-transcriptionally regulate gene and bio-protein expression, and then adjust mi- toehondrial oxidative stress, has important influence on the process of sepsis and prognosis. Here, a current review of how microRNA impinge on mitochondrial dysfunction in sepsis was performed.