载γ-球蛋白微包纳载体的制备与性能

Preparation and characterization of NEMs loading γ-globulin

为了结合不同载体的特点从而实现更佳的性能,载体的集成化研究已日益成为研究者关注的热点。为了延长微胶囊的释放时间,构筑了新型的微包纳载体形式并用于大分子药物γ-球蛋白的包埋及释放。所制备的微包纳胶囊表面光洁,球形度较好,胶囊之间无粘连,分散性较好,粒度分布均匀。几丁聚糖分子量、浓度及药物初始浓度对载药量及体外释放影响不一。与单纯微胶囊相比,微包纳胶囊能够显著延长药物的释放时间,从而为该新型载体在大分子药物释放的应用方面提供了实验依据。

To combine the characteristics of different carriers for better properties, carrier combination has been a hot field in recent years. In this article, a novel nanoparticles embedded microcapsules （NEMs） was constructed for the encapsulation and release of macromolecular drug γ-globulin to extend the release period of microcapsules. The prepared NEMs showed smooth surface, good sphericity and dispersity. The capsules had no adhesion and were well distributed. The drug initial concentration, chitosan molecular weight and concentration on drug loading and release in vitro were investigated. Compared with microcapsules, NEMs could extend the release period obviously, and it would supply experimental data in the future application of NEMs in macromo lecular drug release.